Job description

Scientists / Senior Scientists

Non-Viral Delivery and Molecular Biology

Excision BioTherapeutics (“Excision”) is a pre-IPO biotechnology company developing novel CRISPR-based therapies to cure viral infectious diseases and improve the lives of chronically ill patients by eliminating viral genomes from infected individuals.

Excision recently announced dosing of the first participant for Phase 1/2 Trial of EBT-101 CRISPR-based therapeutic for treatment of HIV patients.

The research site of Excision is located in Cambridge, MA. For more information about the company, please visit https://www.excision.bio

Job Summary and Responsibilities:

Our Discovery/R&D - Genome Editing Research Team is seeking two highly motivated scientists to advance our preclinical programs for infectious diseases. The incumbents will work closely with a collaborative group of genome editing experts, virologists, bioinformaticians, preclinical scientists and clinicians. Selected candidates will have an opportunity to contribute to the CRISPR gene editing field and company growth.

________________________________________________________________________

Scientist / Senior Scientist, Nonviral Delivery

Key responsibilities include, but are not limited to:

· Designing and executing research experiments to advance our lead programs

· Recording, summarizing and presenting experimental results in internal and external meetings

· Troubleshooting experimental problems and improving the quality of data

· Managing external companies, CROs and vendors to keep project timeline on track

· Designing and testing synthetic guide RNAs and mRNA

· Evaluating new editing platforms

Qualifications:

· PhD in Molecular / Cell Biology, Genetics, or related discipline with 0-3 years of post graduate experience or M.S. with 5+ years of industry experience

· Hands-on experiences with mammalian cell culture and non-viral gene delivery

· In-depth knowledge in molecular biology

· Previous experience in one or more of the following areas is a strong plus: CRISPR guide RNA screening, off-target assessment, lipid nanoparticle, next-generation sequencing, primary cell culture, protein engineering and DNA repair

· Strong work ethics and communication skills to build collaborative relationships with team members

· Ability to work in a fast-paced environment

Scientist / Senior Scientist, Molecular Biology

Key responsibilities include, but are not limited to:

· Designing and executing complex research experiments to advance our lead programs

· Applying state-of-the-art technologies to analyze the CRISPR gene editing outcomes

· Developing and executing bioanalytical assays

· Leading sample analysis from pre-clinical and IND-enabling animal studies

· Optimizing AAV vectors for efficient CRISPR/Cas9 delivery

· Effectively collaborating with an integrated team to ensure the success of projects; communicating and presenting research findings to various stakeholders

· Overseeing and collaborating with CROs and academic labs

Qualifications:

· PhD in Molecular / Cell Biology, Genetics, or a related discipline with minimum of 5+ years’ experience in molecular biology

· Demonstrated scientific productivity as indicated by a strong publication record or equivalent accomplishments in the industry

· Previous experience in one or more of the following areas is a strong plus: bioanalytical assay development, ddPCR, CRISPR gene editing, AAV gene therapy, infectious diseases

· Strong skills in critical thinking and problem solving

· Strong interpersonal and communication skills with the ability to build open and collaborative relationships with the team

· Ability to work in a fast-paced environment

We are an equal opportunity employer. Qualified candidates - please forward your cv, in confidence.

Job Type: Full-time

Pay: From $120,000.00 per year

Benefits:

• 401(k)
• 401(k) matching
• Dental insurance
• Employee assistance program
• Flexible schedule
• Flexible spending account
• Health insurance
• Life insurance
• Paid time off
• Vision insurance

Schedule:

• 8 hour shift

Supplemental pay types:

• Bonus pay

Ability to commute/relocate:

• Watertown, MA 02472: Reliably commute or planning to relocate before starting work (Required)

Work Location: Hybrid remote in Watertown, MA 02472

oacadventures.ca is the go-to platform for job seekers looking for the best job postings from around the web. With a focus on quality, the platform guarantees that all job postings are from reliable sources and are up-to-date. It also offers a variety of tools to help users find the perfect job for them, such as searching by location and filtering by industry. Furthermore, oacadventures.ca provides helpful resources like resume tips and career advice to give job seekers an edge in their search. With its commitment to quality and user-friendliness, oacadventures.ca is the ideal place to find your next job.